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1 edition of clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults found in the catalog.

clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults

clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults

a systematic review and economic analysis

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Published by Gray Publishing on behalf of NCCHTA in Tunbridge Wells .
Written in English


Edition Notes

StatementW. Clark ... [et al.].
SeriesHealth technology assessment 2004 -- vol.8, no.18
ContributionsClark, W., National Co-ordinating Centre for HTA (Great Britain)
The Physical Object
Paginationx, 118 p. :
Number of Pages118
ID Numbers
Open LibraryOL22116941M

Anakinra in rheumatoid arthritis. A randomized, double- blind, multicenter mono-therapy trial involving patients with active and severe RA, showed that 43% of patients receiving mg/day compared with placebo, achieved an ACR20 response. Patients were randomized to either plac ebo or anakinra at doses of 30, 75 or mg/day for 24 weeks.   anakinra targets interleukin-1, a chemical your body makes that causes inflammation. your doctor will call this type of drug an "il-1 blocker.

  The TRACK [Treatment of Rheumatoid Arthritis and Comorbidities with Kineret (anakinra)]-study: a randomized, open-label multicenter study assessing the efficacy of anakinra in lowering HbA1c (glycated hemoglobin) as well as changes in DAS28 in Rheumatoid Arthritis (R.A.) patients with type 2 diabetes (T2D) Authors: R. Giacomelli,(A,B) P. Detailed Anakinra dosage information for adults and children. Includes dosages for Rheumatoid Arthritis and Cryopyrin-Associated Periodic Syndrome; plus renal, liver and dialysis adjustments.

you take anakinra by injection.. THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. biological therapies for rheumatoid arthritis. NICE suggest that: on the balance of its clinical benefits and cost effectiveness, anakinra is not recommended for the treatment of rheumatoid arthritis (RA), except in the context of a controlled, long-term clinical study.


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Clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults Download PDF EPUB FB2

The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis. W Clark, P Jobanputra, P Barton Cited by: The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis.

Health Technol Assess. May;8(18):iii-iv, ix-x, The clinical and cost-effectiveness of anakinra for the treatment of rheumatoidarthritis in adults: a systematic review and economic by: To review the evidence of the clinical and cost-effectiveness of anakinra, an interleukin-1 receptor antagonist (IL-1Ra), for the treatment of rheumatoid arthritis (RA) in adults.

The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: A systematic review and economic analysis.

To review the evidence of the clinical and cost-effectiveness of anakinra, an interleukin-1 receptor antagonist (IL-1Ra), for the treatment of rheumatoid arthritis (RA) in onic bibliographic by: The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis By Wendy Clark, Paresh Jobanputra, Pelham Barton and.

The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis. Health Technol Assess, 8 (), pp. Medline.

The efficacy of anakinra in RA was studied in a 24‐week, multicenter, randomized, double‐blind, placebo‐controlled study reported by Bresnihan et al in In that study, patients were randomized to 1 of 4 treatment groups: anakinra 30 mg/day, anakinra 75 mg/day, anakinra mg/day, or placebo.

There was a significant improvement in number of participants achieving ACR20 (38% versus 23%) who were treated with anakinra 50 to mg daily versus placebo after 24 weeks.

This 15% increase in patients achieving ACR20 with anakinra versus placebo is felt to be a clinically meaningful, though modest, outcome.

Final Appraisal Determination. Anakinra for rheumatoid arthritis. 1 Guidance On the balance of its clinical benefits and cost effectiveness, anakinra is not recommended for the treatment of rheumatoid arthritis, except in the context of a controlled, long-term clinical study. The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis By W Clark, P Jobanputra, P Barton and A Burls Year: Author: W Clark, P Jobanputra, P Barton and A Burls.

The IL-1Ra Arthritis Study Group. Arthritis Rheum. ; 4. Clark W, Jobanputra P, Barton P, Burls A. The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis.

Health. Anakinra for the treatment of RA- TAR WMHTAC Confidential Page 7 07/04/ Version for website publication Summary Description of technology This report reviews the evidence of the clinical and cost-effectiveness of anakinra, an interleukin-1 receptor antagonist (IL-1Ra), for the treatment of rheumatoid arthritis in adults.

On the balance of its clinical benefits and cost effectiveness, anakinra is not recommended for the treatment of RA, except in the context of a controlled, long-term clinical study.[] Patients currently receiving anakinra for RA may suffer loss of wellbeing if their treatment were discontinued at a time they did not anticipate.

For rheumatoid arthritis, coverage was extended to etanercept, adalimumab, and anakinra in addition to the previously covered infliximab. We undertook to develop a model to compare the costs and quality‐adjusted life years (QALYs) generated by each of the 4 biologic by:   Objective.

To perform a systematic review of clinical effectiveness and safety of anakinra in rheumatoid arthritis (RA). Methods. We searched Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, and the reference lists of included articles for randomized controlled trials comparing anakinra to placebo in adults with RA.

Results. Five trials Cited by: CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): What is the clinical effectiveness and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis (RA) in adults who have not responded to conventional disease modifying anti-rheumatic drug (DMARD) treatments.

C Clarification of the research question and scope Anakinra (TN: Kineret) offers a new. On the balance of its clinical benefits and cost effectiveness, anakinra is not recommended for the treatment of rheumatoid arthritis, except in the context of a controlled, long-term clinical study.

Patients currently receiving anakinra for rheumatoid arthritis may suffer loss of wellbeing if their. The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis. Health Technol Assess May; 8(18): 1– Google Scholar; 2.

American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis. Anakinra has been approved by the Food and Drug Administration to treat rheumatoid arthritis in adults and children, but it has not been approved for use in adults or children with atopic dermatitis and is considered an experimental treatment in this study.

Anakinra is used to treat the symptoms of moderate to severe rheumatoid arthritis in adults. Anakinra may also help slow the progress of the disease. Anakinra may also help slow the progress of .Final version Page 2 19/08/ B Full title of research question What is the clinical effectiveness and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis (RA) in adults who have not responded to conventional.

Clark W, Jobanputra P, Barton P, Burls A. The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults: a systematic review and economic analysis.

Health Technol Assess. ;8: 1– pmid .